Leaky Gut – Leaky gut and the PANDA test: what's behind it?

In short: “Leaky gut” refers to a more permeable intestinal lining. In naturopathy it is linked to various complaints; in conventional medicine it is not an established diagnosis. Lab tests such as the PANDA test or stool markers can give clues.

What is leaky gut?

Leaky gut means that the intestinal lining is less tight than normal. As a result, substances that should stay in the gut can pass into the body more easily and keep the immune system busy.

How can it develop?

It doesn't happen overnight. When the gut flora is out of balance, food is digested less well. Unwanted bacteria can multiply, and their metabolic products can irritate the intestinal lining. If you also eat a lot of foods you don't tolerate well, the lining can become inflamed and more permeable.

The immune system is then constantly busy. In naturopathy this is linked to tiredness, intolerances or susceptibility to infections.

How is leaky gut assessed?

PANDA test: PANDA stands for Platelets Analysed Number in Different Anticoagulants. The blood is mixed with two different anticoagulants (heparin and citrate) and the number of platelets is compared. If the values differ, this can point to increased permeability. However, the test is not generally recognised.

Gut diagnostics with alpha-1-antitrypsin and zonulin: these two markers can be measured in a stool analysis. Alpha-1-antitrypsin can indicate an irritated or more permeable intestinal lining; zonulin is involved in regulating permeability. Together with the gut microbiome, this gives a much more complete picture.

No single value is meaningful on its own. I always look at the results together with your symptoms.

And what does the panda have to do with it?

Nothing – it's just in the name of the test. 😉

When should I see a doctor first?

Blood in the stool, unintended weight loss, fever or severe pain should be checked by a doctor first.

How I help rebuild the gut: Gut restoration.

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