Nitrosative stress – Nitrosative stress: what's behind it?

In short: Nitrosative stress describes an overload of the cells by nitrogen compounds. In naturopathy it is linked to exhaustion, pain or sleep problems. The scientific picture is still unclear.

What is nitrosative stress?

Nitrosative stress refers to the increased formation of nitrogen compounds such as nitric oxide (NO) and the more aggressive peroxynitrite. Peroxynitrite forms when NO and superoxide meet. It can damage enzymes that normally break down harmful molecules – creating a cycle that puts further strain on the cells.

What can it do in the cells?

Put simply, stressed cells work less well. Possible effects discussed include:

• hormone-producing cells
• the production of messengers such as serotonin and dopamine
• melatonin production and therefore sleep
• the body's detoxification capacity

Possible triggers

• viral, bacterial or parasitic infections
• physical injuries, especially to the head and cervical spine
• severe psychological stress
• certain medications (e.g. antibiotics, statins, beta-blockers) – never stop medication without consulting your doctor
• a diet very high in nitrates, e.g. lots of smoked food

Often a trigger meets a body that is already out of balance.

Typical complaints

Symptoms are often vague, for example:

• lack of energy and exhaustion
• pain
• low mood
• sleep problems
• digestive complaints

In naturopathy, nitrosative stress is linked to chronic fatigue syndrome (CFS), fibromyalgia or IBS, among others. Its role has not yet been scientifically established.

When should I see a doctor first?

New or severe symptoms, signs of paralysis, persistent low mood or unexplained exhaustion should be checked by a doctor first.

As a naturopath, I help you identify stresses and support your body in a targeted way. More here: Naturopathy.

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